From what I can tell Hannah and Joe very much prefer old-school cRPGs, warts and all. So they are probably not expecting their games to be a mainstream success and are probably fine with creating games that appeal to a more niche hardcore audience. That said, it seems like even most of the people in their target audience can only take so much punishment.
The reviewer here seemed to be complaining about stats actually mattering, i.e, "If I create a melee expert, he can't hit anything with guns!" Well, yeah, if you want to use guns your character needs the skill to use them. But if the disadvantages are really that harsh hopefully they'll tune those down.
The game went through so many visual styles over the course of the development.. it's funny that it ended up looking quite similar to Serpent in the Staglands.
Although it's probably wise to wait for further patches, I'm thinking of trying out the game today, but I will make a stealth oriented character. Not sure how viable that will be.