Mass Effect 2 - E3 Previews @ GameSpot, IGN

Mass Effect 2 is next along in coverage of BioWare's titles at E3.  Here's GameSpot:

Mass Effect 2 will not only feature new dialogue options, but new combat options as well. For example, you will now be able to issue separate move and attack orders to squadmates individually. The power wheel remains, so you can still pause the action and issue orders. However, BioWare aims to make real-time action a more viable alternative than ever. To this end, we watched an extended sequence as Shepard fought his way across the space station. BioWare showed off multiple physics-based attacks that sent Shepard's vanguard enemies flying, as well as shooting and cover mechanics that resembled those of the first game. There are nine new classes of weapons, including heavy weapons, such as a missile launcher that we saw in action. That particular weapon wreaked havoc on multiple turrets and looked appropriately powerful.

...and IGN:

The coolest change to the combat is that enemies now have individual hit boxes on all of their body parts. Shoot a robot in the arms or legs and you can watch them slowly tear to bits as they're ripped limb from limb. Shoot one in the head and watch the machine brains go flying. The same location sensitive damage also applies to human and other living beings. Head shots here we come.