I've found one thing which quite annoys me. If you're in a fight and get close to an NPC with a dialogue trigger, then he will start his dialogue while the critter is eviscerating you, or you can be attacked while in the middle of a conversation which you can't leave and suffer the same fate!! That needs to be fixed.
Yes, most irritating. Or two npcs with the second npc dialogue interupting the first, suddenly I'm in a fight I can't do (yet) and die, unsure where in the story I've rezzed.
The quest/story threading feels chaotic at times, I don't feel I have enough information to make some decisions, so I'm taking the "maybe later" option a lot. Some of the dialogue seems to assume I've done something or know something.
I am enjoying the game but have some reservations. It took me a long time to really get into first Elex, so I am hoping this is going to be the same.