Fallout 4 - 5 Issues with Survival Mode

@Techraptor they discuss how the upcoming survival mode will affect game balance and builds.

Perk choices are going to be much different than non-Survival gameplay

The changes to the perk system in Fallout 4 have been equally lauded and derided for different reasons. I'm largely a fan of it myself. I think it makes planning characters a bit easier, and there are several complementary perk choices that can provide for interesting builds.

For example, one of the combinations I personally use is Strong Back 4, Action Boy/Girl 2, and Moving Target 3. Strong Back 4 gives me extra carry weight, lets me jog while overburdened at the cost of AP as if I were sprinting, and allows me to Fast Travel while overburdened. Action Boy/Girl refreshes my Action Points at a faster rate, and Moving Target 3 makes sprinting (or jogging while overburdened) use less AP overall. This combination of perks allows me to stay constantly on the move without ever having to worry much about carry weight because I am a terrible person who likes to pick up absolutely everything that isn't nailed down.

However, these perks might not be as helpful in Survival Difficulty. For example, Strong Back 4 as it is would be rendered completely useless as you can't Fast Travel at all. You run the risk of losing health and suffering limb damage while overburdened as well. This particular build may not be viable in Survival Difficulty.

Aside from some perks just outright not working anymore, other perks will likely need to be changed in some fashion. For example, will Cannibalism increase your Fatigue? Can you counteract the downsides of it with higher levels of the perk? There's not really much detail in how some of the more game-changing perks are going to interact with the new mechanics and how they might be changed for Survival Difficulty.