Deus Ex: Human Revolution

Deus Ex: Human Revolution is set in 2027, just as human augmentation begins to enter mainstream life, and is the first game in the timeline (Deus Ex is set in 2052, Deus Ex: Invisible War is set in 2072).

Augmentations are not the advanced nanotechnological augmentation used by the two protagonists of the previous games, JC or Alex Denton, they are mechanical augmentation, the type of augmentation used by Gunther Hermann or Anna Navarre for example in Deus Ex.